Not necessarily....if your Ground is say the odd one out you play 11 there and 11 on bigger grounds. Chance to adapt to both.I don't see it as that big a deal really. Apart from some small adjustments in setting up zones, it is hardly mentioned by teams preapring to play there. I'd bet if you asked every coach 100% would say they would rather adjust to a smaller ground than a bigger one.
Having said that it is also true that if your home ground gives you a significant advantage because of it's difference in size, it must also give you a significant disadvantage every other week.
If your ground is one of the bigger you play 21 on bigger 1 on tiny, far less chance to adapt.